硕士研究生《检验医学进展》课程将于下周继续上课，具体安排如下：
时间 | 讲座题目 | 主讲人 | 地点 | 上课对象 |
3月27日（周一）上午9：00 | RNA binding protein, Ybx2, regulates RNA stability during cold-induced brown fat activation | 徐聃 | 同心楼六楼会议室 | 2016级硕士研究生 |
徐聃
Dr. Xu is a Senior Research Fellow in the Program inCardiovascular and Metabolic Disorders, Duke-NUS Medical School Singapore. Shereceived her Ph.D from Case Western Reserve University in 2011. From 2011-2012,she underwent postdoctoral fellowship training at Harvard Medical School inBoston, MA. Because of family reason, she moved to Singapore and continued herpostdoc training in Duke-Nus Medical School in 2013. Her research focuses onepigenetic regulation of adipocyte development.
讲座简介
Recent years have seen an upsurge ofinterest in understanding the mechanisms underlying brown adipose tissue (BAT)development and activation. How these processes are regulated at thepost-transcriptional level, however, has yet to be fully understood. Toinvestigate roles for RNA binding proteins (RBPs) in BAT, we conducted RNA-seqto systemically profile >400 RBPs in different adipose depots, during whiteadipose tissue browning, and during brown adipogenesis, leading to theidentification of Y-box binding protein 2 (Ybx2), a BAT-enriched RBP. Knockdownof Ybx2 blocks brown adipogenesis in vitro, while its overexpressionpromotes BAT marker expression in brown and white adipocytes. Ybx2 knockout mice can form BAT but fail toactivate a full thermogenic program. Integrative analysis of RNA-seq and RNA-immunoprecipitationfollowed by RNA-seq (RIP-Seq) revealed a set of Ybx2’s mRNA targets, includingPgc1α, that were destabilized by Ybx2 depletion. Thus, Ybx2 is a novelregulator orchestrating BAT activation.
